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. 2011 Oct 6:442–550. doi: 10.1016/B978-1-4377-0798-4.00004-9

Table 4-5.

Examples of Positive and Negative Interference on Biochemistry Analytes Induced by Sample Hemolysis

Analyte Effect of Hemolysis*
Alanine transaminase Minimal effect
Alkaline phosphatase Increased
Bilirubin Increased
Chloride Decreased
Creatinine Increased
Inorganic phosphate Increased
Lipase Decreased
pH Decreased
Potassium No detectable effect
Total calcium Increased
Total protein Increased
Urea nitrogen Increased
*

Type and degree of interference vary among different testing modalities unique to individual laboratories or in-hospital biochemistry analyzers.