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. 2020 Feb 20;29(6):1018–1029. doi: 10.1093/hmg/ddaa029

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© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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VPS39 controls localization of the pericentriolar pool of IFT20 trough autophagy. (A) IFT20 centrosomal dynamics in serum deprivation. IFT20 (green) accumulates up to 24 h after serum deprivation and decreases during prolonged starvation around the centrosome, marked with γtubulin (red). (B) IFT20 (green) accumulates around the centrosome in VPS39-silenced (siVPS39) cells (top middle panel and dark gray bar in the graph) and in cells treated with Bafilomycin (BafA1, lower panel and light gray bar in the graph) compared to controls (top first panel and white bar in the graph). The accumulation is rescued in siVPS39 cells treated with Tat-Beclin1 (TatB-1). Bars = 10 μm. Hoechst (blue) was used to stain nuclei. Data are presented as the mean ± SEM. Two-way Anova test was used to evaluate significance ^***P-value < 0.005. n = number of replicates.