Table 2.
Univariate and Multivariate Analyses: Clinicopathological Factors, PT/Fbg System Score, and Overall Survival.
| Variables | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | |
| Gender | ||||||
| Male vs female | 1.117 | 0.664-1.881 | .677 | |||
| Age (years) | ||||||
| <57 vs ≥57 | 1.320 | 0.940-1.855 | .109 | |||
| TNM stage | ||||||
| I-II vs III-IV | 5.044 | 3.592-7.083 | <.001 | 2.754 | 1.836-4.131 | <.001 |
| T stage | ||||||
| T1-2 vs T3-4 | 4.611 | 3.298-6.445 | <.001 | |||
| Node stage | ||||||
| N0 vs N1-2 | 4.102 | 2.618-6.424 | <.001 | |||
| Distant metastases | ||||||
| Yes vs No | 3.300 | 1.930-5.641 | <.001 | |||
| Treatment | ||||||
| Resection vs local ablation vs Interventional therapy vs other | 1.670 | 1.422-1.961 | <.001 | 1.299 | 1.068-1.579 | .009 |
| ECOG | ||||||
| 0-1 vs 2 | 0.300 | 0.042-2.149 | .231 | |||
| Alcohol behavior | ||||||
| Yes vs no | 0.948 | 0.668-1.347 | 0.767 | |||
| Family history of cancer | ||||||
| Yes vs no | 0.668 | 0.420-1.063 | .089 | |||
| HBs Ag | ||||||
| Negative vs positive | 0.444 | 0.294-0.670 | <.001 | 0.563 | 0.329-0.963 | .036 |
| HBe Ag | ||||||
| Negative vs positive | 0.886 | 0.486-1.612 | .691 | |||
| HBc Ab | ||||||
| Negative vs positive | 0.399 | 0.238-0.670 | .001 | 0.707 | 0.361-1.387 | .313 |
| LSR | ||||||
| ≥1.065 vs <1.065 | 2.222 | 1.591-3.103 | <.001 | 1.677 | 1.141-2.465 | .008 |
| GPS | ||||||
| Score 0 vs 1 vs 2 | 2.991 | 2.377-3.764 | <.001 | 1.390 | 0.991-1.950 | .057 |
| PT/Fbg system | ||||||
| Score 0 vs 1 vs 2 | 2.671 | 2.083-3.426 | <.001 | 1.899 | 1.334-2.705 | <.001 |
Abbreviations: CI, confidence interval; GPS, Glasgow Prognostic Score; HBs Ag, hepatitis B surface antigen; HBe Ag, hepatitis B e-antigen; HBc Ab, hepatitis B core antibody; LSR, ALT/AST ratio; PT/Fbg, prothrombin time and fibrinogen.