Figure 4.

HIPEC with rmhTNF+RTX could significantly inhibit the tumor growth and had good therapeutic effect on the CRC-PC xenograft model. (a) Scheme and schedule of imaging and treatments. (b) The tumors in mice were visualized by in vivo imaging system before or after a course of chemotherapy. Representative images of each group were shown above. (c) The fluorescence intensities were quantitatively analyzed by Kodak in vivo imaging system. Each point stood for an independent mouse. (d) The representative macroscopic views of tumor nodules in each group were shown. (e) The pathology system scores of tumor nodules were evaluated by e PCI scoring after mice were sacrificed and dissected. Each group had six mice. Results represented mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 (Mann–Whitney U test). rmhTNF: recombinant mutant human TNF-α; RTX: raltitrexed; HT: hyperthermia; HIPEC: hyperthermic intraperitoneal chemotherapy; e PCI: peritoneal cancer index. (A color version of this figure is available in the online journal.)