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. 2020 Feb 1;8(1):61. doi: 10.3390/vaccines8010061

Figure 5.

Figure 5

Vaccine candidates protected mice against a lethal dose of toxins. (A) Survival rates of the pups of mice immunized with BGs and challenged with 2 LD50 CB3, 2 LD50 EV71, or 5 LD50 EV71. In comparison with mice immunized with PBS, all vaccine candidates increased the survival rate (p < 0.001; n = 20 mice/group). (B) Survival rates for the pups of mice immunized with BGs and challenged with 2 LD50 EV71, 2 LD50 CB3, or 5 LD50 CB3. In comparison with mice immunized with PBS, all vaccine candidates increased the survival rate (p < 0.001; n = 20 mice/group). (C) Survival rate (D) body weight changes for wild-type mice immunized with BGs and challenged with 20 LD50 (2 × 109 CFU) of viable E. coli O157:H788321 strain. In comparison with mice immunized with PBS, all vaccine candidates increased the survival rate (p < 0.001; n = 20 mice/group). Similar results were observed in two independent experiments. Survival data were analyzed by log-rank tests. Data are from two independent experiments.