Figure 7.

Select immune-related gene responses at Day 1 predicted T-cell responses to the tularemia vaccine. (A) The bar plots represent regularized linear regression coefficients of the best model for predicting a positive CD8+ response (to the left) and positive CD4+ T cell response (to the right). Boxplots for the top (red) and bottom-ranked genes (blue) with annotations based on the logistic regression coefficient are presented. (B,C) Scatterplots that summarize individual gene associations between peak CD4+ and CD8+ and gene log₂ fold change for the CCL20 and NR4A3 genes (green lines) including locally weighted scatterplot smoothing trend lines (yellow lines). CCL20 and NR4A3 were notably negatively correlated with CD4+ T cell responses and positively correlated with CD8+ responses.