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. 2020 Feb 28;94(6):e01883-19. doi: 10.1128/JVI.01883-19

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Copyright © 2020 Ringe et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Production and antigenicity of B41 SOSIP.v4.1 IO-NP trimers. (A) Surface carboxylate groups on lipid-coated IO-NPs were treated with EDC and sulfo-NHS cross-linking agents. SOSIP trimers were coupled to the activated particles via surface amine groups at pH 8 to create IO-NP trimers. (B) 2G12-capture ELISA analyses of soluble (blue lines and symbols) and IO-NP (red lines and symbols) B41 SOSIP.v4.1 trimers with bNAbs PGT145, VRC01, and PGT121. (C) As in panel B but with non-NAbs 17b, F105, and 19b. (D) As in panel B but with rabbit NAb 16D and non-NAbs C2 and C1.