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. 2020 Feb 28;94(6):e01883-19. doi: 10.1128/JVI.01883-19

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Copyright © 2020 Ringe et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG A7 — Immunogenicity of B41 SOSIP.v4.1 soluble and IO-NP trimers in mice. (A) AUC analysis of the anti-trimer binding Ab ELISA data presented as endpoint titers in Fig. 6B. (B) The immunogenicity of the PADRE tag on B41 SOSIP.v4.1 trimers was assessed by ELISA using a His-tagged version of the PADRE peptide. Pools of sera from bleeds 2 to 5 were tested. Red, bleed 2; green, bleed 3; purple, bleed 4; blue, bleed 5. (C) Negative-stain EM 3D reconstructions of complexes between B41 SOSIP.v4.1 trimers and Fabs derived from group 1 and group 2 sera, showing N289 glycan hole-like antibodies (pink) and base-binding antibodies (purple). We were unable to test Fabs from group 3 and 4 sera with the B41 SOSIP.v4.1-PADRE-v3 immunogen due to limited sample availability.