FIG 6.

Response of biological clones to antiviral agents. The origin of the populations and biological clones is depicted in Fig. 1. Infectious progeny production upon infection of Huh-7.5 reporter cells with HCV p0, HCV p100, HCV p200, or the three biological clones derived from each population (indicated on the left of the panel groups, with symbols given at the top box) at an MOI of 0.03 TCID₅₀/cell, in the absence of any drug (No drug) or the presence of 600 nM telaprevir (TPV), 100 μM ribavirin (Rib), or 800 nM sofosbuvir (SOF). The statistical significance of pairwise differences is given in the boxes below the corresponding virus progeny production plots; they are based on the three progeny titer values using the ANOVA test (*, P < 0.05; ns, not significant). Procedures for infection in the absence and presence of drugs are given in Materials and Methods.