TABLE 3.
A/Sw/13 HA contact residues with MAb C585 and conservation in selected influenza virus HA strains
| Yr | Strain | Binding scorea |
Contact residueb
in HA epitope |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 119 | 121 | 122 | 123 | 124 | 168 | 169 | 171 | 172 | 173 | 174 | 176 | 257 | 259 | |||
| 1968 | A/HongKong/8/1968 | 3 | . | I | T | . | G | . | . | . | D | N | . | . | . | . |
| 1971 | A/Bilthoven/21801/1971 | 3 | . | I | T | . | G | . | . | . | D | N | . | . | . | . |
| 1977 | A/Texas/1/1977 | 3 | . | I | . | . | G | . | . | . | D | N | . | . | . | . |
| 1980 | A/Rotterdam/577/1980 | 0 | . | I | . | . | G | . | . | . | G | N | . | . | . | . |
| 1987 | A/Sichuan/2/1987 | 0 | . | I | . | . | D | . | . | . | G | K | . | . | . | . |
| 1994 | A/NewYork/739/1994 | 0 | . | I | . | . | D | . | . | . | G | K | . | . | . | . |
| 1997 | A/Sydney/5/1997 | 3 | . | . | . | . | . | . | . | . | D | K | . | . | . | . |
| 2003 | A/Netherlands/88/2003 | 3 | . | . | . | . | . | . | . | . | . | K | . | . | . | . |
| 2005 | A/Wisconsin/67/2005 | 3 | . | . | D | . | . | . | . | . | . | K | . | . | . | . |
| 2007 | A/Uruguay/716/2007 | 3 | . | . | . | . | . | . | . | . | . | K | . | . | . | . |
| 2007 | A/Brisbane/10/2007 | 3 | . | . | . | . | . | . | . | . | . | K | . | . | . | . |
| 2009 | A/Perth/16/2009 | 3 | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| 2011 | A/Victoria/361/2011 | 3 | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| 2012 | A/Texas/50/2012 | 3 | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| 2013 | A/Switzerland/9715293/2013 | 3 | E | N | N | E | S | M | P | N | E | Q | F | K | Y | K |
| 2014 | A/HongKong/4801/2014 | 3 | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| 2016 | A/Massachusetts/28/2016 | 3 | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| 2016 | A/Singapore/INFIMH-16-0019/2016 | 3 | . | K | . | . | . | . | . | K | . | . | . | . | . | . |
| 2016 | A/Sweden/96/2016 (3C.2a2) | NT | . | K | . | . | . | . | . | . | . | . | . | . | . | . |
| 2017 | A/British_Columbia/003/2017 (3C.2a1) | NT | . | K | . | . | . | . | . | K | . | . | . | . | . | . |
| 2017 | A/Newcastele/77/2017 (3C.3a) | NT | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
a
A KD of <1 nM was given a score of 3, and no detected binding is given a score of 0. NT, nor tested.
b
Residue variations from Sw/13 HA are shown in letters with conserved residues shown as dots.