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. 2020 Feb 28;94(6):e01432-19. doi: 10.1128/JVI.01432-19

FIG 6.

FIG 6

Hemagglutination inhibition (HAI) serum antibody and challenge with H1N1 influenza viruses. HAI titers were determined for each group of mice (n = 11) from blood collected at week 12 postvaccination. (A to D) Mice were vaccinated with either CA/09 VLP (A), Bris/07 VLP (B), V7 VLP (C), or V8 VLP (D) vaccine, and the collected sera were tested against a panel of 9 H1N1 influenza viruses. Values are the geometric mean titers plus standard errors of the means (SEM) (error bars). The dotted lines indicate the 1:40 to 1:80 HAI titer range. (E and F) Kaplan-Meier survival curves for vaccinated mice challenged with A/Brisbane/59/2007 (E) or A/California/07/2009 (F). (G) Mice challenged with A/California/07/2009 were monitored daily for weight loss over a 14-day observation period.