FIG 7.

Hemagglutination inhibition (HAI) serum antibody. HAI titers were determined for each group of mice (n = 11) from blood collected at week 12 postvaccination. Mice were vaccinated as follows: (A) mock; (B) Bris/07 VLP vaccine; (C) CA/09 VLP vaccine; (D) X6 VLP vaccine; (E) V9 VLP vaccine; (F) V10 VLP vaccine; (G) V11 VLP vaccine; (H) V12 VLP vaccine. The collected sera were tested against a panel of 9 H1N1 influenza viruses. The dotted lines indicate the 1:40 to 1:80 HAI titer range. All data are reported as absolute mean values ± SEM. HAI titers were compared using nonparametric one-way ANOVA. All statistical analysis was performed using GraphPad Prism 7 software (GraphPad, San Diego, CA, USA), and a P value of <0.05 was considered statistically significant (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001).