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. 2020 Apr 8;11:460. doi: 10.3389/fphar.2020.00460

Figure 1.

Figure 1

DP inhibits angiogenesis in vivo and in vitro. (A, D) Tube formation of HUVECs on Matrigel. Cells were treated with CM derived from 0, 100, 200, and 400 mg/L DP treated HepG2 cells for 48 h. (B) The newly formed blood vessels on the chick embryo chorioallantoic membrane (CAM) after treated with DP (0, 100, 200, and 400 mg/L) for 48 h. (C, E) Histopathological analyses of tumor growth in mice xenografted with Hepa1-6 and H22 cancer cells. The tumor sections were subjected to IHC staining using an antibody against CD31. The magnification is 400x. Error bars represent mean ± SD from three independent experiments. (*P < 0.05, **P < 0.01, ***P < 0.001).