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. 2020 Apr 8;11:460. doi: 10.3389/fphar.2020.00460

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Copyright © 2020 Ren, Wu, Yang, Yang, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DP suppresses HUVECs migration and invasion in vitro. (A, B) HUVECs were treated with different concentration (0, 100, 200, and 400 mg/L) of DP-CM for 0, 24, and 48 h. Migration ability of HUVECs was evaluated by wound healing assay. (C, D) HUVECs treated with different concentration (0, 100, 200, and 400 mg/L) of DP-CM were seeded into the inner chamber. Invasion of HMEC-1 cells were evaluated by a Transwell assay. (E) The effect of DP-CM on HUVECs proliferation was evaluated by CCK-8 assay. (*P < 0.05, **P < 0.01, ***P < 0.001).