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DP inhibits the activation of PI3K/AKT/mTOR pathway. (A) WB analyses of p-PI3K, total AKT, p-AKT and total AKT expression in the HepG2 and Hepa1-6 cells treated or untreated with IGF-1 and DP. (B–D) Proposed mechanism of DP exerts anti-angiogenesis effect on HepG2 and Hepa1-6 cells. no significance (ns), *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
