Table 1.
List of the 12 target taxa in the platform.
| Taxon | Associations | References |
|---|---|---|
| Akkermansia | Inversely associated with metabolic signatures of obesity including insulin resistance and fasting glucose level. Suggested marker for calorie restriction diet efficiency prediction. | [7,[25], [26], [27], [28]]. |
| Bacteroides | One of the dominant genera in adult gut microbiome; linked to “Western diet”. Can change in abundance after high-fiber dietary interventions. | [1,29,30] |
| Bifidobacterium | Dominates in the gut community of healthy infants. Inversely associated with obesity and Crohn's disease. Abundant in certain Eurasian populations. Contains many probiotic strains. Can increase in abundance after intervention with probiotics. | [31] [2,[32], [33], [34]] |
| Blautia | One of the dominant genera in adult gut microbiome. Linked to type 2 diabetes. | [4,33] |
| Christensenellaceae | Inversely associated with obesity and IBD and directly - to Parkinson's disease; members of the family can promote reduction of excessive weight. | [32,35,36] |
| Enterobacteriaceae | Positively associated with metabolic disorders and IBD. | [6,32,37,38] |
| Enterococcus | Linked to inflammation, can carry a wide range of virulence factors and antibiotic resistance genes. Its intestinal domination increases the risk of bacteremia in immunocompromised patients. Prevalent in infant microbiome. | [39,40]; [41]. |
| Lactobacillus | Inversely associated with type 2 diabetes, ulcerative colitis. Contains many probiotic strains. | [25,42] |
| Methanobrevibacter | Linked to eating behavior, anorexia nervosa, body mass index, obesity, IBD. | [[43], [44], [45]] |
| Prevotella | One of the dominant genera in adult gut microbiome. Increased in rural populations of the world. Linked to diet high in fiber and low levels in animal protein and fat. Maternal carriage during pregnancy is reversely linked to food allergy in the offspring. |
[[46], [47], [48]] |
| [Ruminococcus] (from Lachnospiraceae family) | High abundance is linked to IBD. | [49,50] |
| Streptococcus | High abundance is associated with liver cirrhosis, as well as to the increased risk of bacteremia in immunocompromised patients. | [51,52]. [53] |