Table 3.
Clinical trials using drugs to deplete macrophages from the tumor’s microenvironment.
| Target | Drugs | Inhibitor type | Clinical trial | Benefit | |
|---|---|---|---|---|---|
| CSF1R | Pexidartinib | Small molecule | NCT02777710 (2016) (Recruiting) | Metastatic/Advanced Pancreatic or Colorectal Cancers | Unknown |
| DCC-3014 | Small molecule | NCT03069469 (2017) (Recruiting) | Advanced Malignancies | Unknown | |
| LY3022855 | mAb |
NCT03153410 (2017) (Recruiting) NCT02718911 (2016) (Completed) NCT03101254 (2017) (Recruiting) |
Pancreas Adenocarcinoma Advanced Solid Tumors Melanoma |
Unknown | |
| PLX3397 | Small molecule |
NCT01004861 (2009) (Completed) NCT02452424 (2015) (Completed) NCT01349036 (2011) (Completed) NCT02371369 (2015) (Active, not recruiting) |
Solid Tumors Melanoma and Other Solid Tumors Recurrent Glioblastoma Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) |
Unknown | |
| MCS110 | Small molecule | NCT03694977 (2018) (Not yet recruiting) | Gastric Cancer | Unknown | |
| IMC-CS4 | Small molecule | NCT01346358 (2011) (Completed) | Advanced Solid Tumors | Unknown | |
| Cabiralizumab | mAb |
NCT03697564 (2018) (Not yet recruiting) NCT02526017 (2015) (Active, not recruiting) |
Stage IV Pancreatic Cancer | Unknown | |
| SNDX-6352 | mAb | NCT03238027 (2017) (Recruiting) | Solid Tumors | Unknown | |
| JNJ-40346527 | Small molecule | NCT03557970 (2018) (Not yet recruiting) | Acute Myeloid Leukemia | Unknown | |
| ARRY-382 | Small molecule |
NCT02880371, (Recruiting) NCT01316822 (2011) (Completed) |
Acute Myeloid Leukemia Advanced or Metastatic Cancers |
Unknown | |
| BLZ945 | Small molecule | NCT02829723 (2016) (Recruiting) | Advanced Solid Tumors | Unknown | |
| RO5509554 | Small molecule | NCT01494688 (2011) (Completed) | Advanced Solid Tumors | Unknown | |
| NA | Clodronate | Bisphosphonate |
NCT01198457 (2010) (Completed) NCT00009945 (2010) (2003)(Completed with results) NCT00909142 (2009) (Completed) NCT00003232 (2004) (Completed) NCT00127205 (2005) (Active, not recruiting) |
Breast Neoplasms, Prostatic Neoplasms, Multiple Myeloma Stage I or Stage II Breast Cancer Bone neoplasms Hormone Refractory Metastatic Prostate Cancer Primary Breast Cancer |
Treatment with clodronate suggests a benefit in recurrence rates for postmenopausal women with breast cancer Paterson et al., 2012 |
| Zoledronate | Bisphosphonate |
NCT00301873 (2006) (Completed, has results) NCT00885326 (2009) (Active, not recruiting) NCT01345019 (2011), (Active, not recruiting) |
Primary Malignant Glioma High-Risk Neuroblastoma Multiple Myeloma |