Skip to main content
. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Curr Opin Biomed Eng. 2019 Nov 1;12:102–110. doi: 10.1016/j.cobme.2019.10.005

Figure 2.

Figure 2.

Association of TCR–pMHC and TCR–pMHC–CD8 bond patterns with functional outcomes. A-B, TCR forms intrinsic catch bond with agonist (stimulatory) ligands and slip bond with non-agonist (non-stimulatory) ligands. C-D, TCR and CD8 form Lck- and CD3-dependent dynamic catch with negative selection ligands and slip bond with positive selection ligands.