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. 2020 Apr 8;13:51. doi: 10.3389/fnmol.2020.00051

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Copyright © 2020 Simon, Wiegreffe and Britsch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mouse Bcl11 predicted protein isoforms. (A) Alternative splicing of Bcl11a leads to four isoforms containing 1, 3, or 6 C2H2 zinc-finger domains required for DNA-binding. Exon 1 and 2 are common to all but the Bcl11a-XS isoform containing the NuRD interacting domain and a C2HC zinc-finger domain involved in protein-protein interaction. (B) Alternative splicing of Bcl11b results in three isoforms containing either all four exons or lacking exon 3 or exon 2 and 3. All Bcl11b isoforms contain the C2H2 zinc-finger domains and NuRD interacting domain. Bcl11b isoform a and b retain the C2HC zinc-finger domain which is missing in isoform c.