Table 4.
Association between genotypic frequency of polymorphism of the interleukin 1 alpha (IL-1α) position-889 and tinnitus in elderly
| Occupational noise exposure | Genotyping | With tinnitus | No tinnitus | P-value |
|---|---|---|---|---|
|
|
|
|
||
| N (%) | N (%) | Chi-square test | ||
| No history | Genotypic frequency | |||
| CC | 3 (20.0) | 2 (3.8) | P = 0.047* χ 2 = 5.641 | |
| TT | 2 (13.3) | 19 (36.5) | ||
| CT | 10 (66.7) | 31 (59.6) | ||
| Allelic frequency | P = 0.580χ 2 = 3.825 | |||
| C | 16 (53.3) | 35 (33.7) | ||
| T | 14 (46.7) | 69 (66.3) | ||
| With history | Genotypic frequency | |||
| CC | 4 (33.3) | 2 (6.9) | P = 0.087χ 2 = 4.457 | |
| TT | 3 (25.0) | 8 (27.6) | ||
| CT | 5 (41.7) | 19 (65.5) | ||
| Allelic frequency | ||||
| C | 13 (54.2) | 23 (39.7) | P = 0.328χ 2 = 1.451 | |
| T | 11 (45.8) | 35 (60.3) |
*Statistically significant association.Marchiori, et al.: IL-1α gene polymorphism and susceptibility to tinnitus