TABLE 1.
Studies suggesting a link with skin carcinogenesis
| PEELING FORMULATION | MATERIALS/SUBJECTS | RESULTS | STUDIES |
|---|---|---|---|
| Animal models | |||
| GA (1–7mg/cm2, pH 3.0) | Guinea pigs | Enhanced redness and swelling without increased PGE2 production or COX-2 protein expression | Park et al32 |
| 35% TCA | UV-irradiated hairless mice | Tumor formation mostly in TCA-treated sites; reduced total tumor count | Dainichi et al33 |
| Human models | |||
| 40% + 60% TCA | Normal human skin | Reduced epidermal LCs in treated vs. control area on Day 7 | Sakai et al34 |
| Jessner’s + 35% TCA, 70% GA + 40% TCA | Humans | Eruptive keratoacanthomas | Mohr et al35; Cox et al36 |
GA: glycolic acid; PGE2: prostaglandin E2; COX: cyclooxygenase; TCA: trichloracetic acid; LCs: Langerhans cells