Table 2.

Linear regression showing the association of white matter hyperintensity (WMH), education, and their interaction with depressive symptoms and different cognitive domains.

Group	Variables	unstandardized β [95% CI]
		GDS		Processing speed		Working memory		Language		Memory
LLD	Intercept	4.97	[-12.35, 22.28]	-0.78	[-4.34, 2.77]	1.46	[-2.26, 5.18]	0.62	[-2.72, 6.72]	2.00	[-2.72, 6.72]
	Age	0.02	[-0.16, 0.20]	-0.02	[-0.06, 0.01]	-0.03	[-0.07, 0.00]	-0.02	[-0.10, 0.00]	-0.05	[-0.10, 0.00]
	Gender	-2.00	[-4.02, 0.01]	0.15	[-0.26, 0.57]	-0.12	[-0.55, 0.31]	0.01	[-0.45, 0.65]	0.10	[-0.45, 0.65]
	Education	-0.10	[-0.52, 0.31]	0.13**	[0.05, 0.21]	0.06	[-0.03, 0.14]	0.05	[-0.07, 0.15]	0.04	[-0.07, 0.15]
	WMH	-1.32	[-3.8, 1.16]	-0.10	[-0.61, 0.41]	-0.05	[-0.58, 0.48]	0.11	[-0.90, 0.45]	-0.22	[-0.09, 0.45]
	WMH x Education	-0.96*	[-1.87, -0.04]	0.10	[-0.09, 0.29]	0.11	[-0.09, 0.30]	0.23*	[0.02, 0.44]	0.05	[-0.20, 0.30]
NC	Intercept	-3.93	[-17.82, 9.96]	1.83	[-3.45, 7.12]	-3.25	[-9.63, 3.12]	-0.52	[-7.20, 6.15]	2.28	[-5.36, 9.93]
	Age	0.13	[-0.01, 0.26]	-0.05	[-0.1, 0.01]	-0.03	[-0.10, 0.03]	-0.04	[-0.11, 0.02]	-0.03	[-0.10, 0.05]
	Gender	0.71	[-0.64, 2.05]	0.39	[-0.12, 0.91]	-0.13	[-0.74, 0.49]	0.24	[-0.40, 0.89]	0.42	[-0.32, 1.16]
	Education	-0.24	[-0.40, -0.07]	0.08*	[0.01, 0.14]	0.05	[-0.02, 0.13]	0.12**	[0.04, 0.20]	0.07	[-0.02, 0.16]
	WMH	0.17	[-1.97, 2.30]	0.07	[-0.74, 0.88]	-1.38*	[-2.36, -0.40]	-0.46	[-1.49, 0.56]	0.52	[-0.65, 1.70]
	WMH x Education	0.09	[-0.25, 0.43]	-0.05	[-0.18, 0.08]	0.14	[-0.02, 0.30]	0.00	[-0.17, 0.16]	-0.14	[-0.33, 0.05]

LLD, Late-life depression; NC, normal control; p < 0.05*; p < 0.005**