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. 2020 Apr 8;11:234. doi: 10.3389/fphys.2020.00234

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Copyright © 2020 Kumari, Mohan, Ecelbarger, Saxena, Gupta, Prasad and Tiwari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MicroRNA 451 in human urinary exosomes (uEs) and its association with kidney disease. (A) Box and whisker plots and scatter plot of the uEmiR-451 fold expression in healthy subjects (n = 23) and kidney disease patients (n = 38). 18S ribosomal RNA was used as control gene to calculate the fold expression of miR-451 using the formulae 2^–ΔCT. Values were log transformed. Whiskers extend down to smallest value and up to largest value. *p < 0.0001 was calculated by Mann–Whitney test. (B) Scatter plot shows Pearson’s correlation between the uE miR-451 fold expression and estimated glomerular filtration rate (eGFR) with a best fit line curve. A significant negative correlation was found between miR-451 and eGFR.