Table 1.

Variables used to assess the response to the initial fluid bolus of 30 mL/kg

Variable	Cutoff value for considering an insufficient response
Mean arterial pressure	< 65 mm Hg
Heart rate	> 120 beats/min
Central venous pressure	> 6 mm Hg
Lactate clearance	< 20%/2-h
Central venous O2 saturation	< 70%
Central venous–arterial PCO2 difference	> 6 mm Hg
Urine output	< 0.5 mL/kg/h
Capillary-refill time	> 3.0 s
Skin mottling	Present