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Aromatase activity of identified CYP19A1 variants. Variants were built into the mammalian expression vector containing wt CYP19A1 cDNA. HEK293 cells were transiently transfected with wt and variant CYP19A1 plasmids, and aromatase activity was assessed by the tritiated water-release assay testing conversion of androstenedione to estrone. Compared to wt, all variants except p.R264C showed complete loss of activity. *P value is less than or equal to .05.
