Fig. 7.

Measurement of BDNF. a) Effect of LXA4 (100 ng/ml) on BDNF secretion by RIN5F cells in vitro that was suppressed by AL (6 mM)/BP (1.5 mM)/STZ (20 mM)/ DB(100 ng/ml). All values expressed as mean ± SEM. § P < 0.001 Vs untreated control, and #P < 0.001 Vs toxin-treated group. b) Effect of combined treatment with sub-optimal doses of AA (10 μg/ml) and LXA4 (50 ng/ml) on the secretion of BDNF that was suppressed by AL (6 mM)/ BP (1.5 mM)/ STZ (20 mM)/DB (100 ng/ml) by RIN cells invitro. All values expressed as mean ± SEM. *P < 0.01; § P < 0.05 Vs untreated control; ₰P < 0.001 Vs toxin group; ^aP ≤ 0.05: AA10 Vs T + AA10; L50 Vs T + L50; AA10 + L50 Vs T + AA10 + L50) and ^#P ≤ 0.01: T + AA10 Vs T + AA10 + L50; T + B50 Vs T + AA10 + L50). All the above set of experiments were done in triplicate (n = 3) and all values expressed as mean ± SEM