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. 2020 Apr 15;15(4):e0220163. doi: 10.1371/journal.pone.0220163

Fig 1. Long-term proliferation of MSCs, expressed as cumulative population doublings.

Fig 1

Proliferation of MSCs from two donors (D6 and D13) was evaluated in cell culture media supplemented with hPL-PIPC or hPL-PIPL after passage 3 (indicated by the vertical dotted line). Points represent mean ± SEM at the end of each passage (n = 6 cell cultures per passage, assessed in two independent experiments). Asterisks (* p < 0.05) indicate statistical significance between hPL-PIPC and hPL-PIPL for an individual donor, evaluated via a two-way ANOVA with Tukey’s post hoc test.