Table 2. Inter- and intra-observer intraclass correlation coefficient (ICC) scores and the 95% confidence interval (CI) for the quantitative terminal ductal lobular unit involution measures obtained from two observers and the automated method.

	Intra-observer ICC (95% CI)*		Inter-observer ICC (95% CI)#
	Observer 1	Observer 2	Observer 1 vs 2	mean(observers) vs automated
Number of TDLUs per tissue area (mm2)	0.96 (0.86, 0.99)	0.82 (0.78, 0.98)	0.71 (0.51, 0.83)	0.80 (0.63, 0.90)
Median TDLU span (μm)	0.91 (0.69, 0.98)	0.90 (0.67, 0.98)	0.81 (0.67, 0.90)	0.57 (0.19, 0.77)
Median number of acini per TDLU	0.91 (0.69, 0.98)	0.86 (0.53, 0.96)	0.73 (0.54, 0.85)	0.80 (0.62, 0.89)

*Intra-observer ICC was evaluated using 10 out of the 40 cases.

^#Inter-observer ICC was evaluated using 40 cases.