Table 3. Inter- and intra-observer Fleiss’ Kappa for qualitative terminal ductal lobular unit assessment among three observers using 40 and 10 cases, respectively.

	Intra-observer*						Inter-observer#
	Observer 1		Observer 2		Observer 3		Observer 1,2 & 3		Consensus vote of observers vs automated
	κ	p-value	κ	p-value	κ	p-value	κ	p-value	κ	p-value
Predominant lobular type
by Russo et al. [2]	0.167	0.598	0.608	0.055	0.798	0.012	0.529	<0.01	0.536	<0.01
Lobular classification according to Baer et al. [9]	0.048	0.880	1.000	<0.01	0.798	0.012	0.370	<0.01	0.538	<0.01

*Intra-observer evaluation was done using 10 out of the 40 cases.

^#Inter-observer evaluation was done using 40 cases.