Fig 8. Summary of the sites at which mutation of CMT2-associated genes affect cellular function and animal behaviour in C. elegans.

Mutations in dyn-1 and unc-116 led to defects in cholinergic motor neuron morphology, while mutations in lin-41, dyn-1, unc-116, fzo-1, osm-9, cua-1, hsp-25, hint-1 and nep-2 resulted in irregularities in the body wall muscle. Neuromuscular junction dysfunction occurred as a result of lin-41, dyn-1, unc-116 and fzo-1 mutations, whereas lin-41, dyn-1, unc-116, fzo-1, osm-9, cua-1, hsp-25 and nep-2 mutants experienced motility impairments in swimming and/or crawling.