Table 4. Effects of the combinations of AraS/AEA with TET against MRSA strains.
| MRSA strain | Agents | Planktonic growth | Biofilm formation | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MIC, μg/ml | FIC, μg/ml | FICI | Effect | MBIC, μg/ml | FBIC, μg/ml | FBICI | Effect | ||
| CI | AraS | >256±0 | 30.2±5.3 | <0.5≤1 | partial synergy | 32±0 | 16±0 | <0.5≤1 | partial synergy |
| TET | 32±0 | 16±0 | 32±0 | 16±0 | |||||
| ATCC 33592 | AraS | 28.4±7.1 | 28.4±7.1 | >1<4 | indifferent | 30.2±5.3 | 33.8±12.5 | >1<4 | indifferent |
| TET | 32±0 | 2±0 | 32±0 | 2±0 | |||||
| ATCC 43300 | AraS | 128±0 | 32±0 | <0.5≤1 | partial synergy | 30.2±5.3 | 16.9±6.3 | <0.5≤1 | partial synergy |
| TET | 32±0 | 16±0 | 32±0 | 2±0 | |||||
| CI | AEA | >256±0 | 7.6±1.3 | <0.5≤1 | partial synergy | 30.2±5.3 | 15.1±2.7 | <0.5≤1 | partial synergy |
| TET | 32±0 | 16±0 | 32±0 | 16±0 | |||||
| ATCC 33592 | AEA | >256±0 | 15.1±2.7 | <0.5≤1 | partial synergy | 33.8±12.5 | 15.1±2.7 | <0.5≤1 | partial synergy |
| TET | 32±0 | 16±0 | 32±0 | 16±0 | |||||
| ATCC 43300 | AEA | >256±0 | 8±3.5 | <0.5≤1 | partial synergy | >256±0 | 14.2±3.5 | ≤0.5 | synergy |
| TET | 32±0 | 16±0 | 32±0 | 1±0 | |||||
Data are presented as means ± SD of three independent experiments performed in triplicate (n = 9).