Subgroup analysis of LMR in pNEN patients graded by WHO criteria. (A) Kaplan–Meier curve for relapse-free survival stratified by tumor grade. (B) Distribution of LMR among patients harboring different tumor grades. Kaplan–Meier curves for relapse-free survival stratified by LMR in the subgroups of G1 (C), G2 (D) and G3 (E) patients. LMR, lymphocyte-to-monocyte ratio; pNEN, pancreatic neuroendocrine neoplasm; WHO, World Health Organization; HR, hazard ratio; CI, confidence interval.