Table 2.
Microbiological findings from clinical specimens collected from the family cluter infected with 2019 novel coronavirus, at presentation
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 7 | |||
|---|---|---|---|---|---|---|---|---|
| Interval between sample collection and symptom onset (days) | 7 | 6 | 9 | 10 | NA | 7 | ||
| Conventional RT-PCR | .. | .. | .. | .. | .. | .. | ||
| Nasopharyngeal swab | .. | .. | .. | .. | .. | .. | ||
| RdRp | + | + | ND | + | ND | + | ||
| Spike | + | + | ND | + | + | + | ||
| Throat swab | .. | .. | .. | .. | .. | .. | ||
| RdRp | NA | NA | ND | ND | ND | + | ||
| Spike | NA | NA | ND | + | + | + | ||
| Serum | .. | .. | .. | .. | .. | .. | ||
| RdRp | ND | ND | NA | NA | NA | NA | ||
| Spike | ND | + | NA | NA | NA | NA | ||
| Plasma | .. | .. | .. | .. | .. | .. | ||
| RdRp | NA | NA | ND | ND | ND | NA | ||
| Spike | NA | NA | ND | ND | ND | NA | ||
| Urine | .. | .. | .. | .. | .. | .. | ||
| RdRp | ND | ND | ND | ND | ND | NA | ||
| Spike | ND | ND | ND | ND | ND | NA | ||
| Stool | .. | .. | .. | .. | .. | .. | ||
| RdRp | NA | NA | ND | ND | ND | NA | ||
| Spike | NA | NA | ND | ND | ND | NA | ||
| Real-time RT-PCR (spike gene) | .. | .. | .. | .. | .. | .. | ||
| Nasopharyngeal swab | + (Ct 31) | + (Ct 27) | ND | + (Ct 31) | ND | + (Ct 27) | ||
| Throat swab | NA | NA | ND | ND | + (Ct 40) | + (Ct 33) | ||
| Sputum | NA | NA | NA | NA | + (Ct 27) | + (Ct 25) | ||
| Serum | ND | + (Ct 40) | NA | NA | ND | NA | ||
| Plasma | NA | NA | ND | ND | ND | ND | ||
| Urine | ND | ND | ND | ND | ND | NA | ||
| Stool | NA | NA | ND | ND | ND | ND | ||
| FilmArray RP2 plus (nasopharyngeal swab only) | ND | ND | ND | ND | ND | ND | ||
| Xpert Xpress Flu/RSV (nasopharyngeal swab only) | ND | ND | ND | ND | ND | ND | ||
| FilmArray GI panel (faecal sample only) | NA | NA | ND | ND | NA | NA | ||
Ct values for real-time RT-PCR presented in parentheses. Ct=cycle threshold. NA=not available. +=positive. ND=not detected. RdRp=RNA-dependent RNA polymerase. RP2=respiratory panel 2. Flu=influenza. RSV=respiratory syncytial virus. GI=gastrointestinal.