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. 2016 Mar 22;106(2):144–159. doi: 10.1002/bip.22808

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© 2016 Wiley Periodicals, Inc.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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6A and 6P KLH‐conjugated templated immunogens. Top panel: sequence alignment and peptide immunogen constructs (yellow shaded) of 6A and 6P. Middle panel: sequence alignment of H1, H2, H5, H3, and H7 in the region of 6A and 6P, red denotes nonconservative substitutions and green shaded area denotes the highly conserved region between different HA proteins to explain antibody cross‐reactivity. Bottom panel: ELISA of cross‐reactivity of anti‐6A (bottom left panel) or anti‐6P (bottom right panel) IgG against five different HA proteins. Coated HA proteins are from influenza A viruses: H1N1, A/Solomon islands/3/06 (NR‐15170); H2N2, A/Singapore/1/57 (NR‐2668); H5N1, A/Laos/3295/06 (NR‐13509); H3N2, A/Uruguary/716/07 (NR‐15168); H7N7, A/Netherlands/219/03 (NR‐2633). Negative control was the IgG isolated from pre‐immune sera (H1N1 HA protein coated on the plate).