Table 1.

Frequently utilized serologic tests for screening of donor and recipient prior to transplantation

Tests Commonly Obtained in Both Donor and Recipient

Human immunodeficiency virus (HIV) antibody (HIV‐1 and HIV‐2 commonly obtained)

Human T cell lymphotropic virus (HTLV)‐I/II antibody

HSV (herpes simplex) IgG antibody (at some centers)

Cytomegalovirus (CMV) IgG antibody

Hepatitis C (HCV) antibody

Hepatitis B (HBV) surface antigen (HBsAg)

Hepatitis B core antibody (HBcAb IgM and IgG)

Hepatitis B surface antibody (HBsAb) at some centers

Rapid plasma reagin (RPR)

Toxoplasma antibody (especially in heart recipients)

Epstein‐Barr virus (EBV) antibody panel*

Varicella‐zoster virus (VZV) antibody*

Other Screening Measures for Infectious Diseases

PPD skin testing (all candidates, preferably with anergy panel)

Strongyloides serology, consider use of stool ova and parasites for candidates from endemic areas

Coccidioides serology (for candidates from endemic areas)

Trypanosoma cruzi serology (for donors and recipients from endemic areas)

Possible Future Recommendations for Screening

West Nile virus (note recent recommendation for NAT testing of live donors, see text)

HHV‐8 (KSHV)

HHV‐6 (in pediatric transplantation)*

*Particularly important in pediatric transplant candidates who are much more likely to be seronegative