Table 2.

Summary of the mutations in Cosmc identified in human tumor cell lines and mouse fibrosarcoma and neuroblastoma cells.

Human cancer and tumor cell lines	Tn/STn expression	Mutation of Cosmc gene	Change in Cosmc protein	Activity	Ref.
human cervical cancer	Tn and STn	deletion of functional allele (LOH)	no protein made	0	61
human Jurkat (E6.1, I2.1, I9.2)	Tn	deletion of T at position 473	ORF shift; N‐terminal 168 aa peptide	2–5 %	60 and unpublished data for I2.1 and I9.2
human LSC	Tn and STn	insertion of T at position 53	ORF shift; N‐terminal 28 aa peptide	0	61
human LS174T clone I	Tn and STn	deletion of A at position 482	ORF shift; N‐terminal 170 aa peptide	5 %	61
human LS174T clone II	Tn and STn	G553T	G185*	5 %	61
human LOX	Tn and STn	deletion of the promoter (no transcript)	no protein made	0	61
mouse fibrosarcoma	Tn and STn	deletion of C509–A587	deletion of T170–L195	NT[a]	287
mouse neuroblastoma (Neuro2a, C1300)	Tn and STn	G301T	E101*	NT[a]	287

[a] Not tested. * indicates a stop codon.