Figure 6.

Capsid breathing in HBV monitored by tandem MS: ¹⁵N‐labeled cp dimers of HBV were incubated with preassembled unlabeled capsids. At certain times native MS spectra were recorded and either T=3 or T=4 capsids of HBV were selected for CID. Subunit exchange was detected in the T=3 capsids after prolonged times as judged by the growth of a signal assigned to labeled monomers, which were ejected from the capsids in tandem MS. Reproduced by permission of the PCCP Owner Societies from Ref. 176.