Figure 1.
Inhibition of the ATPase activity of the SCV helicase by various bismuth complexes. a) ATPase activity of the SCV helicase in the presence of a 50 μm (left) or 1 μm (right) concentration of various potential inhibitors. ATPase activity is expressed as a percentage of the activity in the absence of inhibitor (representing 100 %). b) Titration of the ATPase activity of the SCV helicase with RBC in the presence of 1 μm U24 (□), the presence of 1 μm (dT)24 (▵), or in the absence of polynucleotide (○). Data have been normalized with respect to the activity in the absence of inhibitor.