Figure 2.

a) ICP‐MS profile spectra of 15 DNA targets with four levels of concentrations. In consideration of some mass overlaps, isotopes of REEs were chosen for the simultaneous determination, including ⁸⁹Y, ¹³⁹La, ¹⁴⁰Ce, ¹⁴¹Pr, ¹⁴⁶Nd, ¹⁴⁷Sm, ¹⁵³Eu, ¹⁵⁸Gd, ¹⁵⁹Tb, ¹⁶³Dy, ¹⁶⁵Ho, ¹⁶⁶Er, ¹⁶⁹Tm, ¹⁷²Yb, and ¹⁷⁵Lu. ¹¹⁵In was monitored as an internal standard in the experiments. Additionally, 15 clinically relevant genetic targets, respectively related to HAV, HBV, HCV, HIV, HPV, EV, TP, VV, B. anthracis, F. tularensis, SARS, coronavirus, breast cancer, prostate cancer, Alzheimer’s disease, as well as sickle cell disease, were simultaneously analyzed with four concentrations of 5, 10, 15, and 20 pmol. The internal standard target was 10 pmol. b) The internal calibration curves of relative intensities of ¹⁷⁵Lu/¹¹⁵In versus the concentrations of the SCD targets (containing blank sample). For other calibration curves, see the Supporting Information, Figure S3.