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. 2009 Jan 19;48(8):1378–1398. doi: 10.1002/anie.200802092

Figure 7.

Figure 7

Nonviral delivery of siRNAs. A) Lipoplex: cationic lipids (gray) form complexes with the negatively charged siRNAs (red). PEG (yellow) is frequently attached to improve the pharmacokinetic characteristics. B) Liposomes in which the cationic lipids enclose the siRNA. C) siRNA coupled to cholesterol to increase its lipophilicity. D) Specific delivery by coupling of siRNAs on the antigen‐binding fragment of an antibody through positively charged protamine. E) Direct coupling of an siRNA to an aptamer for tumor‐cell‐specific delivery. F) Neuronal delivery by a peptide of the rabies virus glycoprotein (RVG) with an arginine nonamer (9R) at its carboxy terminus to bind the siRNA. G) Receptor‐mediated delivery by coupling of a ligand (F: Folate) to a DNA oligonucleotide (blue), that hybridizes with siRNA (sense strand: green, antisense strand: red). Further details are described in the text.