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Overview of the most important characteristics of viral vectors.
|
Retroviral vectors |
Adenoviral vectors |
Adeno‐associated virus vectors |
|
|---|---|---|---|
|
transduction of quiescent cells |
no—onco‐retrovirus yes—lentivirus |
yes |
yes |
|
genomic integration |
yes |
no |
no (or limited) |
|
potential risks |
insertional mutagenesis |
immune reaction, cytotoxicity |
cytotoxicity |
