Skip to main content
. 2012 Jan 31;51(8):1778–1802. doi: 10.1002/anie.201102762

Figure 1.

Figure 1

a) Comparison of unliganded protease with open conformation flaps (PDB code 1HHP64 in cyan) and protease in complex with a substrate analogue (PDB code 2AOD64 in magenta) showing closed conformation flaps. The catalytic residues Asp25 and Asp25′ and the peptide analogue are shown as stick models. b) Interactions of the protease with the peptide analogue of the p2/NC cleavage site (ace‐Thr‐Ile‐Nle‐r‐Nle‐Gln‐Arg, where Nle is norleucine substituting for Met in the natural peptide sequence and r indicates the reduced peptide bond) (PDB code 2AOD).64 The conserved hydrogen‐bonding interactions are shown as green dotted lines, and nonconserved hydrogen bonds are indicated by black dashed lines.