Table 1.
Enzyme inhibitory potency of 10 against wild‐type and mutant proteases.
|
Enzyme |
K i [pm] |
K i mut/K i wt |
Vitality |
|---|---|---|---|
|
wild type |
14 |
1 |
1 |
|
D30N |
<5 |
0.33 |
0.3 |
|
V32I |
8 |
0.57 |
0.5 |
|
I84V |
40 |
2.85 |
1 |
|
V32I/I84V |
70 |
5 |
0.7 |
|
M46F/V82A |
<5 |
0.33 |
0.1 |
|
G48V/L90M |
<5 |
0.33 |
0.1 |
|
V82F/I84V |
7 |
0.5 |
0.1 |
|
V82T/I84V |
22 |
1.57 |
0.1 |
|
V32I/K45I/F53L/A71V/I84V/L89M |
31 |
2.2 |
0.1 |
|
V32I/L33F/K45I/F53L/A71V/I84V |
46 |
3.3 |
0.1 |
|
20R/36I/54V/71V/82T |
31 |
2.2 |
0.1 |