Table 12.
Comparison of the antiviral activity of 29, 30 , and of other PIs against multidrug‐resistant HIV‐1 variants.
|
Virus[a] |
IC50 [μm] (fold change) |
|||
|---|---|---|---|---|
|
APV |
DRV |
29 |
30 |
|
|
HIV‐1ERS104pre (wild type) |
0.030 |
0.0037 |
0.020 |
0.0029 |
|
HIV‐1MDR/B |
0.93 (31) |
0.036 (10) |
>1 (>50) |
0.029 (10) |
|
HIV‐1MDR/C |
0.26 (9) |
0.013 (4) |
>1 (>50) |
0.022 (7) |
|
HIV‐1MDR/G |
0.38 (12) |
0.0023 (1) |
0.27 (13) |
0.0045 (2) |
|
HIV‐1MDR/TM |
0.19 (6) |
0.0019 (1) |
0.041 (2) |
0.0031 (1) |
[a] Amino acid substitutions identified in the protease‐encoding region compared to the consensus type B sequence cited from the Los Alamos database, see reference 130 for details.