Table 13.

Anti‐HIV activity of 34 against selected clinical isolates highly resistant to multiple protease inhibitors.

Virus[a]	Phenotype	EC50 [μm]
		IDV	APV	LPV	DRV	GRL‐02031 (34)
HIV‐1ERS104pre (wild‐type)	X4	0.028	0.025	0.03	0.0036	0.028
HIV‐1TM (MDR)	X4	>1 (>36)	0.25 (10)	0.73 (24)	0.0036 (1)	0.029 (1)
HIV‐1MM (MDR)	R5	>1 (>36)	0.32 (13)	0.72 (24)	0.019 (5)	0.042 (2)
HIV‐1C (MDR)	X4	>1 (>36)	0.35 (14)	0.32 (11)	0.015 (4)	0.023 (1)
HIV‐1G (MDR)	X4	0.29 (10)	0.33 (13)	0.14 (5)	0.014 (4)	0.027 (1)

[a] Amino acid substitutions identified in the protease‐encoding regions of HIV‐1_ERS104pre, HIV‐1_TM, HIV‐1_MM, HIV‐1_C, and HIV‐1_G compared to the consensus B sequence cited from the Los Alamos database, see references 131 and 132.