Table 15.

Comparison of the antiviral activity of 39 against multidrug‐resistant clinical isolates.

Virus[a]	Phenotype	EC50 [μm]
		ATV	LPV	DRV	39 (GRL‐0476)
HIV‐1ERS104pre (wild type)	X4	0.0027	0.031	0.004	0.0019
HIV‐1MDR/B	X4	0.470 (174)	>1 (>32)	0.034 (9)	0.0145 (8)
HIV‐1MDR/C	X4	0.039 (14)	0.437 (14)	0.009 (2)	0.0037 (2)
HIV‐1MDR/G	X4	0.019 (7)	0.181 (6)	0.026 (7)	0.0026 (1)
HIV‐1MDR/TM	X4	0.075 (28)	0.423 (14)	0.022 (6)	0.0275 (14)
HIV‐1MDR/MM	R5	0.205 (76)	0.762 (25)	0.017 (4)	0.0050 (3)
HIV‐1MDR/JSL	R5	0.293 (109)	>1 (>32)	0.023 (6)	0.0275 (14)

[a] For details of amino acid substitutions identified in the protease‐encoding region of HIV‐1_ERS104pre, HIV‐1_B, HIV‐1_C, HIV‐1_G, HIV‐1_TM, HIV‐1_MM, and HIV‐1_JSL and the assay protocol, see references 134 and 135.