Table 16.
Antiviral activity of 42, amprenavir (APV), and darunavir (DRV) against multidrug‐resistant clinical isolates in PHA‐PBMCs.
|
Virus[a] |
EC50 [μm] |
||
|---|---|---|---|
|
APV |
DRV |
42 (GRL‐0519) |
|
|
HIV‐1ERS104pre (wild‐type) |
0.032 |
0.005 |
0.0006 |
|
HIV‐1MDR/B |
0.521 (16) |
0.028 (6) |
0.0043 (7) |
|
HIV‐1MDR/C |
0.357 (11) |
0.011 (2) |
0.0009 (2) |
|
HIV‐1MDR/G |
0.485 (15) |
0.031 (6) |
0.0027 (5) |
|
HIV‐1MDR/TM |
0.488 (15) |
0.031 (6) |
0.0022 (4) |
|
HIV‐1MDR/MM |
0.291 (9) |
0.016 (3) |
0.0027 (5) |
|
HIV‐1MDR/JSL |
0.419 (13) |
0.024 (5) |
0.0028 (5) |
[a] See reference 137 for details.