Table 2.

Agents used to prevent and treat influenza: M2 inhibitors (22)

Drug	Suggested dosage	Usual adult dosage1		Dose adjustment state
		Prophylaxis	Treatment
Amantadine		100 mg b.i.d.	100 mg b.i.d.
	5 mg/kg to max of 150 mg in two divided doses			Age 1–9 years
	100 mg q.o.d.			CrCl 30–50 mL/min
	100 mg q.o.d.			CrCl 15—30 mL/min
	100 mg q. week			CrCl 10—15 mL/min
	100 mg q week			CrCl,10 mL/min
	100 mg q.o.d.			Age ≥65 years
Rimantadine		100 mg b.i.d.	100 mg b.i.d.
	5 mg/kg to max of 150 mg in two divided doses			Age 1–9 years2
	100 mg q.o.d.			CrCl,10 mL/min
	100 mg q.o.d.			Severe hepatic dysfunction
	100 mg q.o.d.			Age ≥65 years

¹Duration of treatment is usually 5 days. Duration of prophylaxis depends of the clinical setting.

²Investigational: Not approved for treatment of children by the US Food and Drug Administration and Health Canada.