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. 2003 Aug 1;48(8):2332–2342. doi: 10.1002/art.11100

Figure 3.

Figure 3

Clinical arthritis in collagen‐induced arthritis (CIA) and pristane‐induced arthritis (PIA) in DA.Pia4 and DA.Pia7 congenic rats. Arthritis severity was determined in DA rats (•; n = 13 for CIA and n = 16 for PIA), DA.Pia4 E3/DA rats (▴; n = 16 in each group), and DA.Pia4 E3/E3 rats (▪; n = 7 for CIA and n = 16 for PIA). There were significant differences between DA and DA.Pia4 and DA.Pia7 congenic rats (P < 0.01 for CIA, showing a significant difference beginning on day 17; P < 0.0001 for PIA, showing a significant difference beginning on day 10, as determined by Mann‐Whitney U test). Levels of cartilage oligomeric matrix protein (COMP) and α1‐acid glycoprotein (AGP) were significant in the DA.Pia4 a/a (E3/E3) and DA.Pia4 a/b (E3/DA) rats compared with the DA.Pia4 b/b (DA/DA) rats (a = E3 allele; b = DA allele). The size of the Cia12/Pia4 congenic fragment is depicted in a schematic representation of chromosome 12.