Table 2.

Linkages identified in the (E3 × DA)DA rat CIA experiment and previously identified PIA loci*

Phenotype, SSLP marker	LOD	Inheritance†	CIA QTL‡		PIA QTL‡		Other QTLs
			QTL	Ref.	QTL	Ref.
Maximum arthritis score
D3mit6	3.5	DA	Cia11	20	–	–	–
D4rat109	4.7	DA	Cia3	22	Pia5	16	Aia3, Eau1
D4eno2	7.5	DA	Cia13	20	Pia7	17	Oia2, Ciaa4
D12rat72	6.6	DA	Cia12	20	Pia4	16	Eae5, Eau2
Arthritis onset
D3mit6	2.8	DA	Cia11	20	–	–	–
D4rat109	5.2	DA	Cia3	22	Pia5	16	Aia3, Eau1
D4eno2	10.8	DA	Cia13	20	Pia7	17	Oia2, Ciaa4
D6mgh10	2.9	E3	Cia20	–	Pia3	16	–
D12rat72	7.6	DA	Cia12	20	Pia4	16	Eae5, Eau2
COMP
D4eno2	4.0	DA	Cia13	20	Pia7	17	Oia2, Ciaa4
D12rat72	3.6	DA	Cia12	20	Pia4	16	Eae5, Eau2, Apr1
α1‐acid glycoprotein
D4eno2	5.1	DA	Cia13	20	Pia7	17	Oia2, Ciaa4
D12rat72	8.3	DA	Cia12	20	Pia4	16	Eae5, Eau2, Apr1
Anti‐CII IgG
D1mgh11	3.3	DA	Ciaa6	–	–	–	Eae6, Eae7
D20mgh4	5.8	E3	Ciaa1	22	Pia1	10	Cia1, Eae1, Oia1
IgG rheumatoid factors
D5rat37	3.0	DA	Ciaa5	19	–	–	Apr2
D14wox12	3.2	DA	Ciaa7	–	Pia6	16	Eae10

^*The maximum arthritis score represents the maximum clinical score obtained during the experiment. Arthritis onset represents the first day of visible signs of arthritis after induction of type II collagen–induced arthritis (CIA). Plasma levels of cartilage oligomeric matrix protein (COMP), α₁‐acid glycoprotein, anti–type II collagen (anti‐CII) IgG (reactive with rat type II collagen), and IgG rheumatoid factors were measured as described in Materials and Methods. SSLP = simple sequence‐length polymorphism; PIA = pristane‐induced arthritis; LOD = logarithm of odds; QTL = quantitative trait locus.

^†Inheritance pattern determined as being DA or E3 promoting.

^‡Previously identified CIA QTL in the same chromosome region as the CIA linkage identified in (E3 × DA)DA linkage (see refs.18, 22, 33, and41, 42, 43).